ABSTRACT:

Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.
  
Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in vitro. The same treatment had considerably less effect on normal human breast cells. Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be a simple, effective, and economical treatment for cancer.
11/30/2001; Life Sciences


 

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• Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin:  
  Henry Lai, and Narendra P. Singh, Department of Pharmacology, University of Washington Seattle, WA USA
  
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• Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.
  By Narendra P. Singh*, Henry Lai - Life Scineces
  
• Malaria Drug May Hold Key to Nontoxic Treatment.  
  The Breast Cancer Fund Report
  
• Artemisinin in Cancer Treatment 
  Dr. Narendra P. Singh Department of Bioengineering University of Washington Seattle
  
• Assessment of the safety of artemisinin compounds in pregnancy
  Report of two informal consultations convened by World Health Oroganization.
  
• WHO Informal Consultation on clinical neurological investigations required for patients treated with artemisinin compounds and derivatives:
  Report of an Informal Consultation convened by WHO
  
• Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro
  Huan-Huan Chen *, Hui-Jun Zhou, Xin Fang
  
• Review of Qinghaosu Antimalarial Drug from Traditional Chinese Medicine
  T.T. Hien and N. J. White. Qinghaosu. The Lancet, Vol. 341, pp. 603-608, March 6, 1993.
  
• Herb-based Anti-malaria Drug
  Center of International Dispute - McNeil Jr. DG. New Drug for Malaria Pits U.S. Against Africa. New York Times May 28, 2002.
  

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